Cytokines and their receptors are constitutively expressed by and act on neurons in the central nervous system in both its normal and its pathological state but cytokine overexpression in the brain is an important factor in the pathogenesis of neurotoxic and neurodegenerative disorders. Abstract cytokines are important signaling molecules synthesized by immune cells in peripheral tissues and the blood and by glial cells and other brain resident cells in the central nervous system cns. Interleukin 6 expression in the central nervous system soon after its discovery it was demonstrated that some astrocytoma and glioma lines expressed il 6 when stimulated with il 1 which prompted speculation that il 6 could have a role in the cns 2. Nonimmune tissues including the central nervous system cns cytokines are of particular importance during neural development and function at all stages starting with induction of the neuroepithelium subsequently cytokines in particular the neuropoietic or gp130 family cytokines regulate the self
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