Igg4 related disease igg4 rd formerly known as igg4 related systemic disease is a chronic inflammatory condition characterized by tissue infiltration with lymphocytes and igg4 secreting plasma cells various degrees of fibrosis scarring and a usually prompt response to oral steroids. Igg4 related disease is an immune mediated condition that can affect multiple organ systems common features include igg4 related autoimmune pancreatitis swelling of or within an organ system an inflammatory pseudotumor salivary gland disease which can lead to enlargement of the salivary glands swollen lymph nodes lymphadenopathy skin manifestations and symptoms consistent with . A number of autoimmune diseases that affect diverse organ systems have recently been noted to be related to igg4 autoantibodies the authors review the spectrum of igg4 related disease and the
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