Pathogenesis pathogenesis is the process by which an infection leads to disease pathogenic mechanisms of viral disease include 1 implantation of virus at the portal of entry 2 local replication 3 spread to target organs disease sites and 4 spread to sites of shedding of virus into the environment. Viral pathogenesis viral pathogenesis is a field in rapid evolution reflecting the dynamic development of systems biology and the continuing introduction of new or improved methodologies. Viral pathogenesis this lecture will define and discuss the basic principles of viral pathogenesis the entire process by which viruses cause disease viral disease is a sum of the effects on the host of virus replication and of the immune response. Using this system the viral life cycle has been duplicated we are studying the mechanisms that regulate viral dna replication cell entry immune evasion and gene expression these studies should provide insight into viral pathogenesis as well as the mechanisms regulating epithelial differentiation
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